The preceding five years have brought remarkable advances in our understanding of the primary structure of drug receptors. The roles of certain amino acid residues in binding drugs and effecting receptor function have been proposed. As even more detailed structures become available, the goal of rational design of drug molecules based on predicted fits between the drug and its receptor will be near at hand. Although none of the classical receptors has yet yielded to X‐ray crystallographic analysis, the methods of (...) molecular biology facilitate the production of the large amounts of these rare proteins necessary for crystallization. Receptor proteins share one fundamental characteristic with allosterically regulated enzymes. Both have the structural flexibility that allows information to be transmitted to distant parts of the molecule. We will discuss recent observations about receptor structure and the dynamic nature of drug receptors, and pose questions about the significance of receptor dynamics for drug design. (shrink)

This essay presents imaginary philosophical debates between Heidegger and Freud exploring their views on science, philosophy, their interrelationship and the fundamental philosophical presuppositions of Freud’s metapsychology. In the final section, Heidegger presents a series of criticisms of Freud’s theory, to which ‘Freud’ posthumously responds.

This essay presents imaginary philosophical debates between Heidegger and Freud exploring their views on science, philosophy, their interrelationship and the fundamental philosophical presuppositions of Freud’s metapsychology. In the final section, Heidegger presents a series of criticisms of Freud’s theory, to which ‘Freud’ posthumously responds.

This article considers Ephraim Chambers's Cyclopaedia (2 Vols., 1728) as a work that responded to anxieties about information overload. Chambers drew on Renaissance ideas about summarizing and organizing knowledge—in particular, the humanist practice of keeping a commonplace book. By completing an alphabetical dictionary with due deference to categories, or Heads, he not only offered a convenient summary of knowledge but retained the notion of an encyclopedic circle of arts and sciences. The article also relates this concept of authorial design to (...) debates surrounding the 1710 copyright Statute in England. (shrink)

Research on human genetic variation can present collective risks to all members of a socially identifiable group. Research that associates race or ethnicity with a genetic disposition to disease, for example, presents risks of group discrimination and stigmatization. To better protect against these risks, some have proposed supplemental community-based reviews of research on genetic differences between populations. The assumption behind these appeals is that involving members of study populations in the review process can help to identify and minimize collective risks (...) that otherwise could go unnoticed. In contrast to this position, critics have argued that supplemental community-based reviews are unnecessary, impractical, and morally problematic. This paper is our attempt to advance this debate by distinguishing the various goals of community review and the forms that it can take. (shrink)

Save for Anthropologists, few social scientists have been among the participants in the discussions about the appropriate structure of a ‘Universal Darwinism’. Yet evolutionary theorizing about cultural, social, and economic phenomena has a long tradition, going back well before Darwin. And over the past quarter century significant literatures have grown up concerned with the processes of change operating on science, technology, business organization and practice, and economic change more broadly, that are explicitly evolutionary in theoretical orientation. In each of these (...) fields of study, the broad proposition put forth by Darwin that change proceeds through a process involving variation, systematic selection, renewed variation... has proved both persuasive and powerful. On the other hand, the evolutionary processes involved in these areas differ in essential ways from those we now know are operative in the evolution of biological species. The objective of this essay is to highlight those differences, which a ‘Universal Darwinism’ needs to encompass, if it is to be broad enough to be a theory that is applicable to the evolution of human cultures as well as evolution in biology. (shrink)

Research on human genetic variation can present collective risks to all members of a socially identifiable group. Research that associates race or ethnicity with a genetic disposition to disease, for example, presents risks of group discrimination and stigmatization. To better protect against these risks, some have proposed supplemental community-based reviews of research on genetic differences between populations. The assumption behind these appeals is that involving members of study populations in the review process can help to identify and minimize collective risks (...) that otherwise could go unnoticed. In contrast to this position, critics have argued that supplemental community-based reviews are unnecessary, impractical, and morally problematic. This paper is our attempt to advance this debate by distinguishing the various goals of community review and the forms that it can take. (shrink)

Being able to communicate with students in schools is essential and critical. Richard Burke discusses the significance of communication and other issues in this integral work. In an innovative manner, Communicating With Students in Schools presents an extensive set of exercises for developing skills in communication, leading to better motivation, discipline, and rapport.

In his classic study,The Great Chain of Being, Arthur Lovejoy delineated a complex set of concepts and assumptions which referred to the perfection of God and the fullness of creation. In attempting to distil the basic or ‘unit idea’ which constituted this pattern of thought, he focused on the assumption that ‘the universe is aplenum formarumin which the range of conceivable diversity ofkindsof living things is exhaustively exemplified’. He called this the ‘principle of plenitude’. Lovejoy argued that this idea implied (...) two others—continuity and gradation—and that together these reflected a pre-occupation with the ‘necessity of imperfection in all its possible degrees’, a concern which had pervaded Western thought since Plato and gave rise to the powerful ontology known as the ‘great chain of being’. (shrink)

Pulling up the Ladder discusses how Wittgenstein's early philosophy became widely known largely through the efforts of Russell and other empirically-minded British philosophers, and to a lesser extent, the scientifically-oriented German-speaking philosophers of the Vienna Circle. However, Wittgenstein's primary philosophical concerns arose in a far different context, and failure to grasp this has led to many misunderstandings of the Tractatus. From Brockhaus' investigation of that context and its problems emerges this new interpretation of Wittgenstein's early thought, which also affords fresh (...) insights into the later Wittgenstein. (shrink)

The common focus of these essays is the debate on the nature of science - often referred to by contemporaries as 'natural knowledge' - in Britain during the first half of the 19th century. A study of these debates allow us to see how British science of this period began to cast loose some of its earlier theological supports, but still relied on a moral framework to affirm its distinctive method, ethos and cultural value.

Dismantling Contemporary Deficit Thinking provides comprehensive critiques and anti-deficit thinking alternatives to this oppressive theory by framing the ...

Growing ties to private industry have prompted many to question the impartiality of academic bioethicists who receive financial support from for-profit corporations in exchange for ethics-related services and research. To the extent that corporate sponsors may view bioethics as little more than a way to strengthen public relations or avoid potential controversy, close ties to industry may pose serious threats to professional independence. New sources of support from private industry may also divert bioethicists from pursuing topics of greater social importance, (...) such as the needs of medically underserved communities. To inform ongoing debates about the financing of bioethics and its transparency to those concerned about potential sources of bias, we examined funding disclosures appearing in original research reports in major bioethics journals. Reviewing research published over a 15-year period, we found little evidence that for-profit corporations are influencing bioethics research directly. Instead, we found evidence that a great number of organizations, both public and private, support bioethics research. These findings suggest that worries about the cooption of bioethics research by a few interested stakeholders are greatly overstated and undersupported by available data. (shrink)

: A standard interpretation of Kantian "maxims" sees them as expressing reasons for action, implying that we cannot act without a maxim. But recent challenges to this interpretation claim that Kant viewed acting on maxims as optional. Kant's understanding of maxims derives from Christian Wolff, who regarded maxims as major premises of the practical syllogism. This supports the standard interpretation. Yet Kant also viewed commitments to maxims as essential for virtue and character development, which supports challenges to the standard interpretation, (...) and raises questions about the coherence of Kant's overall conception of the role of maxims in practical philosophy. (shrink)

A new diagnostic modeling system for automatically synthesizing a deep‐structure model of a student's misconceptions or bugs in his basic mathematical skills provides a mechanism for explaining why a student is making a mistake as opposed to simply identifying the mistake. This report is divided into four sections: The first provides examples of the problems that must be handled by a diagnostic model. It then introduces procedural networks as a general framework for representing the knowledge underlying a skill. The challenge (...) in designing this representation is to find one that facilitates the discovery of misconceptions or bugs existing in a particular student's encoding of this knowledge. The second section discusses some of the pedagogical issues that have emerged from the use of diagnostic models within an instructional system. This discussion is framed in the context of a computer‐based tutoring/gaming system developed to teach students and student teachers how to diagnose bugs strategically as well as how to provide a better understanding of the underlying structure of arithmetic skills. The third section describes our uses of an executable network as a tool for automatically diagnosing student behavior, for automatically generating “diagnostic” tests, and for judging the diagnostic quality of a given exam. Included in this section is a discussion of the success of this system in diagnosing 1300 school students from a data base of 20.000 test items. The last section discusses future research directions. (shrink)

Bioethics and feminist scholarship has explored various justice implications of nonmedical sex selection and family balancing. However, prospective users’ viewpoints have been absent from the debate over the socially acceptable bounds of nonmedical sex selection. This qualitative study provides a set of empirically grounded perspectives on the moral values that underpin prospective users’ conceptualizations of justice in the context of a family balancing program in the United States. The results indicate that couples pursuing family balancing understand justice primarily in individualist (...) and familial terms rather than in terms of social justice for women and girls or for children resulting from sex selection. Study participants indicated that an individual’s desire for gender balance in their family is ethically complex and may not be inherently sexist, immoral, or socially consequential, particularly given the social context in which they live. Our findings suggest that the social conditions that contribute to prospective users’ desires for gender balance in their families may direct them away from recognizing or engaging broader social justice concerns relating to sexism and stratified reproduction. (shrink)

My brand of evolutionary economics recognizes, highlights, that modern economies are always in the process of changing, never fully at rest, with much of the energy coming from innovation. This perspective obviously draws a lot from Schumpeter. Continuing innovation, and the creative destruction that innovation engenders, is driving the system. There are winners and losers in the process, but generally the changes can be regarded as progress. The processes through which economic activity and performance evolve has a lot in common (...) with evolution in biology. In particular, at any time the economy is marked by considerable variety, there are selection forces winnowing on that variety, but also continuing emergence of new ways of doing things and often economic actors. But there also are important differences from biological evolution. In particular, both innovation and selection are to a considerable degree purposive activities, often undertaken on the basis of relatively strong knowledge. (shrink)

Like many trained in philosophy, we greatly value the work of those scholars with the courage to espouse contrarian views, particularly when the ideas in dispute lie at the very heart of entrenched...

Strategies for protecting historically disadvantaged groups have been extensively debated in the context of genetic variation research, making this a useful starting point in examining the protection of social groups from harm resulting from biomedical research. We analyze research practices developed in response to concerns about the involvement of indigenous communities in studies of genetic variation and consider their potential application in other contexts. We highlight several conceptual ambiguities and practical challenges associated with the protection of group interests and argue (...) that protectionist strategies developed in the context of genetic research will not be easily adapted to other types of research in which social groups are placed at risk. We suggest that it is this set of conceptual and practical issues that philosophers, ethicists, and others should focus on in their efforts to protect identifiable social groups from harm resulting from biomedical research. (shrink)